Tibetan medicine is one of the oldest traditional medicine systems in the world.Taking the Ruyi Zhenbao tablet (RYZB) as an example, which is a widely used classic oral Tibetan medicine, this article discusses the pharmacokinetics of single administration and long-term treatment and analyzed its metabolic properties and tissue distribution el refor
Peize Zhang,1,* Guanghui Xu,2,* Yanhua Song,3,* Jie Tan,1 Tao Chen,1 Guofang Deng1 1Department of Pulmonary Medicine & Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, People’s Republic of China; 2Jiangmen Institute of Tuberculosis Prevention and Control, Guangdong, People’s Republic of China; 3Department of Tu
Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9 tools.However, it is difficult to precisely assess the editing performance in vivo because the tissues contain many non-targeted cells, which is one of the major barriers to clinical translation.Here, in the Atoh1-GFP;Kcnq4+/G229D mice, recapitulating a novel